For many centuries now, those considering themselves civilized have carried out numerous atrocities—from abductions to dispossession to massacres—against those thought to be less civilized, all in the name of civilization. This has particularly been the case in the last 500 years when Europeans came into contact with indigenous peoples in their voyages of discovery and subsequent settlement. One of the justifications for these offences was often couched in terms of the self-appointed duty of “civilized” Europeans to bring the blessings of civilization to the “savage” and “barbarian” hordes, also called the “white man's burden” or the “burden of civilization.” Many nations took up this sacred trust of civilization and the challenge of bringing enlightenment and salvation to the uncivilized peoples of the world, during which the latter were either subjugated or perished. In this article I trace the intellectual heritage of the sacred trust and note its inherent contradictions, ranging from debates between Sepúlveda and Las Casas over Spain's rights of conquest in the New World to the musings of key Enlightenment thinkers such as Locke, Hegel, Kant, and J. S. Mill. As some of its advocates acknowledge the sacred trust and concomitant civilizing missions were inevitably and invariably violent and went against the very idea of civilization. And as Las Casas deftly highlighted, much of the reasoning underpinning the sacred trust was in the form of “poisons disguised with honey.”